diff --git a/Source/cmake.cxx b/Source/cmake.cxx
index bcd0d755b3..b9acf450b1 100644
--- a/Source/cmake.cxx
+++ b/Source/cmake.cxx
@@ -1619,6 +1619,11 @@ void cmake::SetArgs(std::vector<std::string> const& args)
     this->SetHomeOutputDirectory(cmSystemTools::GetLogicalWorkingDirectory());
   }
 
+  if (this->State->GetRole() == cmState::Role::Script && havePreset) {
+    this->IssueMessage(MessageType::FATAL_ERROR,
+                       "Presets are not supported in CMake script mode.");
+  }
+
 #if !defined(CMAKE_BOOTSTRAP)
   if (presetsArgs.HasPresetsArg()) {
     this->SetArgsFromPreset(presetsArgs, haveBArg);
diff --git a/Tests/RunCMake/CMakePresets/PresetScriptMode-result.txt b/Tests/RunCMake/CMakePresets/PresetScriptMode-result.txt
new file mode 100644
index 0000000000..d00491fd7e
--- /dev/null
+++ b/Tests/RunCMake/CMakePresets/PresetScriptMode-result.txt
@@ -0,0 +1 @@
+1
diff --git a/Tests/RunCMake/CMakePresets/PresetScriptMode-stderr.txt b/Tests/RunCMake/CMakePresets/PresetScriptMode-stderr.txt
new file mode 100644
index 0000000000..ea606e4b63
--- /dev/null
+++ b/Tests/RunCMake/CMakePresets/PresetScriptMode-stderr.txt
@@ -0,0 +1,2 @@
+^CMake Error:
+  Presets are not supported in CMake script mode\.$
diff --git a/Tests/RunCMake/CMakePresets/PresetScriptMode.cmake b/Tests/RunCMake/CMakePresets/PresetScriptMode.cmake
new file mode 100644
index 0000000000..e69de29bb2
diff --git a/Tests/RunCMake/CMakePresets/RunCMakeTest.cmake b/Tests/RunCMake/CMakePresets/RunCMakeTest.cmake
index 95acf52fd3..6660eaa093 100644
--- a/Tests/RunCMake/CMakePresets/RunCMakeTest.cmake
+++ b/Tests/RunCMake/CMakePresets/RunCMakeTest.cmake
@@ -349,6 +349,7 @@ run_cmake_presets(NoPresetArgument --preset)
 run_cmake_presets(NoPresetArgumentEq --preset= -DA=B)
 run_cmake_presets(UseHiddenPreset)
 run_cmake_presets(NoPresetFileArgument --preset GoodNoArgs --presets-file)
+run_cmake_presets(PresetScriptMode -P PresetScriptMode.cmake --preset GoodNoArgs)
 
 # Test CMakeUserPresets.json
 unset(CMakePresets_FILE)