diff --git a/Modules/Platform/Darwin-Initialize.cmake b/Modules/Platform/Darwin-Initialize.cmake
index d518ac9779..fe42de163d 100644
--- a/Modules/Platform/Darwin-Initialize.cmake
+++ b/Modules/Platform/Darwin-Initialize.cmake
@@ -222,6 +222,10 @@ function(_apple_resolve_multi_arch_sysroots)
     set(_arch_sysroot "")
     foreach(sdk ${_sdks})
       list(FIND _sdk_archs_${sdk} ${arch} arch_index)
+      # arm64e is a superset of arm64; an SDK listing arm64e supports arm64 binaries.
+      if(arch_index EQUAL -1 AND arch STREQUAL "arm64")
+        list(FIND _sdk_archs_${sdk} "arm64e" arch_index)
+      endif()
       if(NOT arch_index EQUAL -1)
         set(_arch_sysroot ${_sdk_path_${sdk}})
         break()