diff --git a/Source/cmCTest.cxx b/Source/cmCTest.cxx
index 8a94dc5894..6272331165 100644
--- a/Source/cmCTest.cxx
+++ b/Source/cmCTest.cxx
@@ -735,6 +735,17 @@ int cmCTest::ProcessSteps()
   cmMakefile& mf = *script.GetMakefile();
   this->ReadCustomConfigurationFileTree(this->Impl->BinaryDir, &mf);
   this->SetCMakeVariables(mf);
+
+  // Inject variables passed via -D so that ctest_* commands can read them
+  // using mf.GetDefinition(). This matches what cmCTestScriptHandler does
+  // before running a -S script. SetCMakeVariables() (above) only defines
+  // variables that correspond to a CTest Configuration key. Other variables
+  // such as CTEST_PRESET are read directly from the makefile and would
+  // otherwise be invisible here.
+  for (auto const& def : this->GetDefinitions()) {
+    mf.AddDefinition(def.first, def.second);
+  }
+
   // CTEST_TIME_LIMIT may come from CTestCustom.cmake (already in the makefile)
   // or from the config map (just populated by SetCMakeVariables above).
   this->SetTimeLimit(mf.GetDefinition("CTEST_TIME_LIMIT"));
diff --git a/Tests/RunCMake/ctest_test/RunCMakeTest.cmake b/Tests/RunCMake/ctest_test/RunCMakeTest.cmake
index ea399768b6..59cbb801ad 100644
--- a/Tests/RunCMake/ctest_test/RunCMakeTest.cmake
+++ b/Tests/RunCMake/ctest_test/RunCMakeTest.cmake
@@ -45,6 +45,32 @@ endforeach()
   run_ctest(TestPresetGenericVar)
   unset(CASE_TEST_PREFIX_CODE)
 
+  # Verify that CTEST_TEST_PRESET passed via -D on the command line reaches
+  # ctest_test() when ctest is run with -M/-T.
+  set(case_source_dir "${RunCMake_BINARY_DIR}/TestPresetCLIVar")
+  set(case_binary_dir "${RunCMake_BINARY_DIR}/TestPresetCLIVar-build")
+  configure_file(
+    "${RunCMake_SOURCE_DIR}/CMakePresets.json.in"
+    "${case_source_dir}/CMakePresets.json"
+    @ONLY)
+  file(REMOVE_RECURSE "${case_binary_dir}")
+  file(MAKE_DIRECTORY "${case_binary_dir}")
+  file(WRITE "${case_binary_dir}/DartConfiguration.tcl"
+    "BuildDirectory: ${case_binary_dir}\nSourceDirectory: ${case_source_dir}\n")
+  file(WRITE "${case_binary_dir}/CTestTestfile.cmake"
+    "add_test(test1 \"${CMAKE_COMMAND}\" -E true)\n"
+    "add_test(test2 \"${CMAKE_COMMAND}\" -E true)\n"
+    "add_test(test3 \"${CMAKE_COMMAND}\" -E true)\n")
+  set(RunCMake_TEST_BINARY_DIR "${case_binary_dir}")
+  set(RunCMake_TEST_NO_CLEAN 1)
+  run_cmake_command(TestPresetCLIVar
+    ${CMAKE_CTEST_COMMAND}
+    -C Debug
+    -M Experimental
+    -D "CTEST_TEST_PRESET=my-include-preset"
+    -T Test
+    -V)
+
   set(custom_presets_file
     "${RunCMake_BINARY_DIR}/TestPresetFileInclude/custom-presets.json")
   configure_file(
diff --git a/Tests/RunCMake/ctest_test/TestPresetCLIVar-stdout.txt b/Tests/RunCMake/ctest_test/TestPresetCLIVar-stdout.txt
new file mode 100644
index 0000000000..913fad5104
--- /dev/null
+++ b/Tests/RunCMake/ctest_test/TestPresetCLIVar-stdout.txt
@@ -0,0 +1 @@
+1/1 Test #[0-9]+: test1 \.+   Passed +[0-9\.]+ sec