diff --git a/Modules/Compiler/GHS-C.cmake b/Modules/Compiler/GHS-C.cmake
index a825b0bbae..9b0d0e8c19 100644
--- a/Modules/Compiler/GHS-C.cmake
+++ b/Modules/Compiler/GHS-C.cmake
@@ -5,6 +5,6 @@ set(CMAKE_C_OUTPUT_EXTENSION ".o")
 
 string(APPEND CMAKE_C_FLAGS_INIT " ")
 string(APPEND CMAKE_C_FLAGS_DEBUG_INIT " -Odebug -g")
-string(APPEND CMAKE_C_FLAGS_MINSIZEREL_INIT " -Ospace")
-string(APPEND CMAKE_C_FLAGS_RELEASE_INIT " -O")
-string(APPEND CMAKE_C_FLAGS_RELWITHDEBINFO_INIT " -O -g")
+string(APPEND CMAKE_C_FLAGS_MINSIZEREL_INIT " -DNDEBUG -Ospace")
+string(APPEND CMAKE_C_FLAGS_RELEASE_INIT " -DNDEBUG -O")
+string(APPEND CMAKE_C_FLAGS_RELWITHDEBINFO_INIT " -DNDEBUG -O -g")
diff --git a/Modules/Compiler/GHS-CXX.cmake b/Modules/Compiler/GHS-CXX.cmake
index 07b5044245..773fe1c214 100644
--- a/Modules/Compiler/GHS-CXX.cmake
+++ b/Modules/Compiler/GHS-CXX.cmake
@@ -5,6 +5,6 @@ set(CMAKE_CXX_OUTPUT_EXTENSION ".o")
 
 string(APPEND CMAKE_CXX_FLAGS_INIT " ")
 string(APPEND CMAKE_CXX_FLAGS_DEBUG_INIT " -Odebug -g")
-string(APPEND CMAKE_CXX_FLAGS_MINSIZEREL_INIT " -Ospace")
-string(APPEND CMAKE_CXX_FLAGS_RELEASE_INIT " -O")
-string(APPEND CMAKE_CXX_FLAGS_RELWITHDEBINFO_INIT " -O -g")
+string(APPEND CMAKE_CXX_FLAGS_MINSIZEREL_INIT " -DNDEBUG -Ospace")
+string(APPEND CMAKE_CXX_FLAGS_RELEASE_INIT " -DNDEBUG -O")
+string(APPEND CMAKE_CXX_FLAGS_RELWITHDEBINFO_INIT " -DNDEBUG -O -g")