diff --git a/Help/cpack_gen/rpm.rst b/Help/cpack_gen/rpm.rst
index b25b822318..a30b4815dd 100644
--- a/Help/cpack_gen/rpm.rst
+++ b/Help/cpack_gen/rpm.rst
@@ -553,6 +553,10 @@ List of CPack RPM generator specific variables:
 
    set(CPACK_RPM_SPEC_MORE_DEFINE "%define __spec_install_post /bin/true")
 
+ .. versionadded:: 4.4
+   If the variable is a list, its string elements will be concatenated using
+   ``\n`` before being substituted into the spec template.
+
 .. variable:: CPACK_RPM_PACKAGE_DEBUG
 
  Toggle CPack RPM generator debug output.
diff --git a/Help/release/dev/CPACK_RPM_SPEC_MORE_DEFINE.rst b/Help/release/dev/CPACK_RPM_SPEC_MORE_DEFINE.rst
new file mode 100644
index 0000000000..e2c4a0fbe2
--- /dev/null
+++ b/Help/release/dev/CPACK_RPM_SPEC_MORE_DEFINE.rst
@@ -0,0 +1,4 @@
+CPACK_RPM_SPEC_MORE_DEFINE
+--------------------------
+
+* The :variable:`CPACK_RPM_SPEC_MORE_DEFINE` could be a list of definitions.
diff --git a/Modules/Internal/CPack/CPackRPM.cmake b/Modules/Internal/CPack/CPackRPM.cmake
index c2b9f42072..75b3b40fae 100644
--- a/Modules/Internal/CPack/CPackRPM.cmake
+++ b/Modules/Internal/CPack/CPackRPM.cmake
@@ -1284,6 +1284,10 @@ function(cpack_rpm_generate_package)
   # CPACK_RPM_SPEC_MORE_DEFINE
   # This is a generated spec rpm file spaceholder
   if(CPACK_RPM_SPEC_MORE_DEFINE)
+    list(LENGTH CPACK_RPM_SPEC_MORE_DEFINE _defines_size)
+    if(_defines_size GREATER 1)
+      list(JOIN CPACK_RPM_SPEC_MORE_DEFINE "\n" CPACK_RPM_SPEC_MORE_DEFINE)
+    endif()
     if(CPACK_RPM_PACKAGE_DEBUG)
       message("CPackRPM:Debug: User defined more define spec line specified:\n ${CPACK_RPM_SPEC_MORE_DEFINE}")
     endif()
diff --git a/Tests/RunCMake/CPack/tests/CUSTOM_BINARY_SPEC_FILE/VerifyResult.cmake b/Tests/RunCMake/CPack/tests/CUSTOM_BINARY_SPEC_FILE/VerifyResult.cmake
new file mode 100644
index 0000000000..20b20c829e
--- /dev/null
+++ b/Tests/RunCMake/CPack/tests/CUSTOM_BINARY_SPEC_FILE/VerifyResult.cmake
@@ -0,0 +1,27 @@
+cmake_path(APPEND bin_dir _CPack_Packages/Linux/RPM/SPECS OUTPUT_VARIABLE SPECS)
+
+file(GLOB specs "${SPECS}/*.spec")
+if(NOT specs)
+  return()
+endif()
+
+set(_pfx multilene_defines_test)
+set(
+    expected_defines
+    "%define ${_pfx}_satu 1"
+    "%define ${_pfx}_dua 2"
+    "%define ${_pfx}_tiga 3"
+  )
+
+foreach(spec IN LISTS specs)
+  file(STRINGS "${spec}" defines REGEX "%define multilene_defines_test_*.")
+  if(NOT defines STREQUAL expected_defines)
+    message(
+        FATAL_ERROR
+        "Multiline definitions mismatch:\n"
+        "      file: `${spec}`\n"
+        "  expected: `${expected_defines}`\n"
+        "    actual: `${defines}`\n"
+      )
+  endif()
+endforeach()
diff --git a/Tests/RunCMake/CPack/tests/CUSTOM_BINARY_SPEC_FILE/test.cmake b/Tests/RunCMake/CPack/tests/CUSTOM_BINARY_SPEC_FILE/test.cmake
index a604863971..da5f6fc072 100644
--- a/Tests/RunCMake/CPack/tests/CUSTOM_BINARY_SPEC_FILE/test.cmake
+++ b/Tests/RunCMake/CPack/tests/CUSTOM_BINARY_SPEC_FILE/test.cmake
@@ -1,5 +1,10 @@
 install(FILES CMakeLists.txt DESTINATION foo COMPONENT test)
 
+set(_pfx multilene_defines_test)
+set(CPACK_RPM_SPEC_MORE_DEFINE "%define ${_pfx}_satu 1")
+list(APPEND CPACK_RPM_SPEC_MORE_DEFINE "%define ${_pfx}_dua 2")
+list(APPEND CPACK_RPM_SPEC_MORE_DEFINE "%define ${_pfx}_tiga 3")
+
 if(PACKAGING_TYPE STREQUAL "MONOLITHIC")
   set(CPACK_RPM_USER_BINARY_SPECFILE "${CMAKE_CURRENT_LIST_DIR}/custom.spec.in")
 elseif(PACKAGING_TYPE STREQUAL "COMPONENT")